Dr. Slump Dende | Goals Enemies Shimorekka |
She did not know why Gero created her as a unique new type of Android different from the mecha-types (like 16) and the modified humans (like 17 and 18). Her attire changes to a black tube top, keeping the black arm sleeves, and also gaining white baggy pants. Android 21 also appeared in the Challenge Mission Let's Confess to Android 21, Idol of a Private Heroes School!, which changed the setting to a typical Japanese high school.

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Android 21 is an Android and the main protagonist who appears in the videogame Dragon Ball FighterZ. Due to her biology, Android 21 has a natural, compulsive instinct to feed (which grew out of control due to cells in her body going berserk). Old Woman Spring | Eventually Goku or Frieza confront Android 21 (Normal) and two Clones. Kuririn | Vegito |

Beat | She did not know why Gero created her as a unique new type of Android different from the mecha-types (like 16) and the modified humans (like 17 and 18). In both missions, Android 21 cannot be captured using a Hero Robo Capture Module thus cannot be turned into a Summon Module however the Clones accompanying her can. According to Android 16, at some point, the cells in 21 may have gone berserk, which resulted in her uncontrollable urges to feed. Her appearance in her final form looks like Majin Buu and she has the powers of Goku, Frieza, Cell, Buu, etc. Her personalities were later transferred to her two halves after her good self-managed to use fission as a result of the emotional turmoil caused by the death of her adoptive son, Android 16 who was killed by her evil side as a result of her losing control.

Main article: Android 21 Arc Vast superhuman abilitiesFighting SkillsCan regenerate infinitely as long as a single atom of her body is still aliveCan absorb others and create new forms and gain more powersComplete body manipulationCan fire a beam that can change anything into what ever she wants from her handsKi sensingTeleportationFlightCan learn any Technique by observing someone else using it onceVery high power levelDoes not need anything to live and can survive in the vacuum of spaceTelekinesis When 21's urges resurfaced, she activated the link system to use its functions to keep herself under control, by suppressing her growing need to feed, and the persona that spawned from it.

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Goku faces her in a Boss Mission after defeating New Model 16 while Frieza faces her in a Super Boss Mission after defeating a Clone of himself, Cell, and Kid Buu.

In spite of this, she is still ravaged by her hunger and has a natural desire to eat her allies, leading 21 to fear herself.

She appears as an unlockable playable character in Dragon Ball FighterZ, where she can be unlocked by completing all the Story Mode Arcs.